反应详情

A solution of 3.63 g (10.7 mmol) of methyl (E)-3-(2-butoxy-3′-methylaminobiphenyl-4-yl)acrylate in 70 ml of methanol is stirred for 4 hours at room temperature in the presence of 363 mg (10% by mass) of 10% palladium-on-charcoal under a hydrogen atmosphere. The palladium is filtered off and the solvent is evaporated off. 3.39 g of methyl 3-(2-butoxy-3′-methylaminobiphenyl-4-yl)propanoate are obtained in the form of a yellowish oil. Yield=93%

1. filtrationThe palladium is filtered off
2. customthe solvent is evaporated off