HCID 67272868, compound → HCID 67272960, compound

Participants

Reaction Steps

In a manner similar to that of Example (18e), by reaction of 400 mg (10% by mass) of 10% palladium-on-charcoal and 4.0 g (8.8 mmol, 1 eq) of methyl (E)-3-[3′-(3-heptyl-1-methylureido)-2-nitrobiphenyl-4-yl]acrylate in 80 ml of methanol, and after purification by chromatography on silica gel (50/50 heptane/ethyl acetate), 3.81 g of methyl 3-[2-amino-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]propanoate are obtained in the form of a colorless oil. Yield=100%

Provenance & Evidence