HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(4-aminobutyl)carbamate → {4-[1-(5-Methyl-pyridin-2-yl)-ethylamino]-butyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(4-aminobutyl)carbamate | HCID 4351 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(5-Methyl-2-pyridinyl)ethanone | HCID 13068663 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {4-[1-(5-Methyl-pyridin-2-yl)-ethylamino]-butyl}-carbamic acid tert-butyl ester | HCID 67272693 | — |
Reaction Steps
Using General Procedure B: Reaction of 1-(5-methyl-pyridin-2-yl)-ethanone (Sundberg, R J et al. J. Am. Chem. Soc. 1969, 91, 658-668) and (4-amino-butyl)-carbamic acid tert-butyl ester in CH2Cl2 with NaBH(OAc)3 gave {4-[1-(5-methyl-pyridin-2-yl)-ethylamino]-butyl}-carbamic acid tert-butyl ester as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863293B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-e608bfea6c0946b3b2b5108bfdfb5156 |
| Source note | uspto-grants-2011_01 |