反应详情

Using General Procedure B, reaction of 1-methyl-1H-imidazole-2-carbaldehyde and (4-amino-butyl)-carbamic acid tert-butyl ester in CH2Cl2 and NaBH(OAc)3 gave {4-[(1-methyl-1H-imidazol-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester as a sticky white foam. 1H NMR (CDCl3) δ 1.43 (s, 9H), 1.50-1.59 (m, 4H), 2.01 (s, 3H), 2.04-2.06 (m, 2H), 2.62-2.73 (m, 2H), 3.08-3.17 (m, 2H), 3.79 (s, 2H), 6.85 (d, 1H, J=2.2 Hz), 7.11 (d, 1H, J=1.8 Hz).