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3-Methylpyridine-2-carboxaldehyde → {3-[(3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylpyridine-2-carboxaldehyde | HCID 1501874 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | [3-(1-Pyridin-2-yl-ethylamino)-propyl]-carbamic acid tert-butyl ester | HCID 67272175 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | {3-[(3-Methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester | HCID 67273022 | — |
反応手順
Using General Procedure B: Reaction of [3-(1-pyridin-2-yl-ethylamino)-propyl]-carbamic acid tert-butyl ester and 3-methyl-pyridine-2-carboxaldehyde with NaBH(OAc)3 in CH2Cl2 gave {3-[(3-methyl-pyridin-2-ylmethyl)-(1-pyridin-2-yl-ethyl)-amino]-propyl}-carbamic acid tert-butyl ester as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07863293B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-c581c2e963814d69bd66612820ad825c |
| 出典メモ | uspto-grants-2011_01 |