Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-1-Boc-piperidine → HCID 58997004, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 3-[1-(4-Fluoro-phenyl)-1-methyl-ethyl]pyridine-2-carbaldehyde | HCID 86594765 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 58997004 | HCID 58997004 | — |
반응 단계
Using General Procedure B: Reaction of 4-amino-piperidine-1-carboxylic acid tert-butyl ester in CH2Cl2 with 3-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-pyridine-2-carbaldehyde and NaBH(OAc)3 gave the amine. 1H NMR (CDCl3) δ 1.10 (m, 2H), 1.43 (s+m, 12H), 1.66 (s, 6H), 2.21 (m, 1H), 2.62 (m, 2H), 3.33 (m, 1H), 3.87 (br d, 2H), 6.97 (t, 2H, J=7.5 Hz), 7.11 (dd, 2H, J=9.0, 3.0 Hz), 7.25 (dd, 1H, J=7.5, 3.0 Hz), 7.86 (d, 1H, J=9.0 Hz), 8.46 (d, 1H, J=3.0 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863293B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-51c23c176ce54ab0894b7d8b1ce3eac2 |
| 출처 메모 | uspto-grants-2011_01 |