HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-{[Bis-(3-methyl-pyridin-2-ylmethyl)-amino]-methyl}-pyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(Bromomethyl)pyridine-2-carbonitrile | HCID 10375450 | — |
| Reactant | Bis-(3-methyl-pyridin-2-ylmethyl)-amine | HCID 45098010 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-{[Bis-(3-methyl-pyridin-2-ylmethyl)-amino]-methyl}-pyridine-2-carbonitrile | HCID 67272304 | — |
Reaction Steps
Using General Procedure A: Reaction of bis-(3-methyl-pyridin-2-ylmethyl)-amine in CH3CN with 2-cyano-3-bromomethyl-pyridine, KI and DIPEA gave 3-{[bis-(3-methyl-pyridin-2-ylmethyl)-amino]-methyl}-pyridine-2-carbonitrile as a dark red oil. 1H NMR (CDCl3) δ 2.04 (s, 6H), 3.86 (s, 4H), 3.99 (s, 2H), 7.07 (m, 2H), 7.38 (m, 3H), 7.84 (d, 1H, J=9.0 Hz), 8.37 (m, 2H), 8.53 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863293B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-78862a23cc974e2abd4dedc0bbe1572f |
| Source note | uspto-grants-2011_01 |