HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Pyridin-2-yl)ethan-1-amine → (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Pyridin-2-yl)ethan-1-amine | HCID 541877 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(2-Trimethylsilylethoxymethyl)-2-formyl-benzimidazole | HCID 12017128 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine | HCID 67272285 | — |
Reaction Steps
Using General Procedure B: Reaction of 1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazole-2-carbaldehyde in CH2Cl2 with 1-pyridin-2-yl-ethylamine and NaBH(OAc)3 gave (1-pyridin-2-yl-ethyl)-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazol-2-ylmethyl]-amine as a pale green oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863293B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-1f8133d42d5c479486c641bc7797bf4e |
| Source note | uspto-grants-2011_01 |