HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium triacetoxyborohydride → (5-Chloro-3-methyl-pyridin-2-ylmethyl)-(1-methyl-1-pyridin-2-yl-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 2-(2-Pyridyl)-2-propylamine | HCID 22736922 | — |
| Reactant | 5-Chloro-3-methylpicolinaldehyde | HCID 72214055 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (5-Chloro-3-methyl-pyridin-2-ylmethyl)-(1-methyl-1-pyridin-2-yl-ethyl)-amine | HCID 67272856 | — |
Reaction Steps
Using General Procedure B: Reaction of 1-methyl-1-pyridin-2-yl-ethylamine and 5-chloro-3-methyl-pyridine-2-carbaldehyde in CH2Cl2 with NaBH(OAc)3 gave (5-chloro-3-methyl-pyridin-2-ylmethyl)-(1-methyl-1-pyridin-2-yl-ethyl)-amine as a beige oil. 1H NMR (CDCl3) δ 1.61 (s, 6H), 2.19 (s, 3H), 3.62 (s, 2H), 4.66 (s, 1H), 7.11-7.15 (m, 1H), 7.38 (s, 1H), 7.48 (d, 1H, J=6.0 Hz), 7.62-7.67 (m, 1H), 8.37 (s, 1H), 8.58 (d, 1H, J=6.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863293B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-e2cc72e094a34577a43c16bffb078698 |
| Source note | uspto-grants-2011_01 |