Potassium Fluoride → HCID 67488146, compound

Participants

Reaction Steps

3-{4-[1-(4-bromo-benzylidene)-3-methyl-butyl]-benzoylamino}-propionic acid methyl ester (2.6 g, 5.86 mmol), 4-t-butyl phenyl boronic acid (2.08 g, 12 mmol), potassium fluoride (1.02 g, 17.6 mmol) and tetrakis(triphenylphosphine)palladium (0.677 g, 0.59 mmol) are placed in a flask. The system is purged with nitrogen. Toluene (40 mL) and water (10 ml) are added and the resulting mixture is refluxed overnight. The reaction is loaded directly onto silica gel and chromatographed using EtOAc/hexanes to yield the titled compound as a yellow oil (0.95 g).

Provenance & Evidence