HCID 11562815, compound → HCID 11611759, compound

HRID 251328Notes

Reaction equation

HRID 251328 reaction equation
[OH:1][C@@H:2]([CH2:35][CH2:36][CH3:37])[C@@H:3]([NH:10][C:11](=[O:34])[CH2:12][C:13]([NH:15][C:16]1[CH:17]=[C:18]([NH:26]C(=O)OC(C)(C)C)[CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1)=[O:14])[CH2:4][NH:5][CH2:6][CH:7]([CH3:9])[CH3:8]>C(Cl)Cl>[NH2:26][C:18]1[CH:17]=[C:16]([NH:15][C:13](=[O:14])[CH2:12][C:11]([NH:10][C@H:3]([C@@H:2]([OH:1])[CH2:35][CH2:36][CH3:37])[CH2:4][NH:5][CH2:6][CH:7]([CH3:8])[CH3:9])=[O:34])[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=1

Participants

3

Reactant 1

HCID 11562815HCID 11562815, compound

Product 1

HCID 11611759HCID 11611759, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A sample of tert-butyl 3-(3-((2S,3S)-3-hydroxy-1-(isobutylamino)hexan-2-ylamino)-3-oxopropanamido)-5-(trifluoromethyl)phenylcarbamate (86 mg, title compound from Example 24) was dissolved in methylene chloride (2 mL). The resultant solution was cooled to 0° C. and charged with trifluoroacetic acid (1 mL). The mixture was allowed to warm to RT and stirred for 45 min before being concentrated in vacuo. The residue was purified by RP-HPLC to afford the TFA salt of the title compound as a white powder after lypholization. MS found: (M+H)+=433.3.

Sources & evidence

ORD record
ord-0045b1432d5142458076c14565f95c99
Source dataset
uspto-grants-2011_01
Patent number
US07863333B2

Reaction notes

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