Piperidine → 1-{3-[4-(4,4-Dimethyl-4,5-dihydro-1,3-oxazol-2-yl)phenoxy]propyl}piperidine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-(3-chloropropoxy)phenyl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole ax10 (0.5 g, 1.87 mmol, 1 eq) and piperidine (0.37 ml, 3.73 mmol, 2 eq) is stirred in a sealed tube at 100° C. overnight. The mixture is then concentrated under vacuum to give 0.8 g of an orange solid. This solid is purified by chromatography on silica gel (eluent: dichloromethane/ethanol 95:5) to obtain 0.49 g of 1-{3-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)phenoxy]propyl}piperidine 1 as an orange oil.

Provenance & Evidence