Potassium Carbonate → HCID 11950364, compound

Participants

Reaction Steps

A mixture of methyl N-[4-(3-piperidin-1-ylpropoxy)benzoyl]serinate ax37 (0.922 g, 2.54 mmol, 1 eq) and (diethylamino)sulfur trifluoride (0.34 ml, 2.78 mmol, 1.1 eq) in dichloromethane (25 ml) is stirred under argon at room temperature for 3.5 h before addition of potassium carbonate (0.35 g, 2.53 mmol, 1 eq). The mixture is stirred for a further 1 h and washed with a saturated solution of potassium hydrogencarbonate and the aqueous layer is extracted with dichloromethane. The organic layers are then dried over magnesium sulfate and concentrated under vacuum to give methyl 2-[4-(3-piperidin-1-ylpropoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxylate ax45 as an orange oil (1.036 g) which is used without further purification.

Provenance & Evidence