HCID 69639922, compound → HCID 69639917, compound

Participants

Reaction Steps

A mixture of methyl N-(1-oxo-4-nitroisoindolin-2-yl)-L-glutamine (6.4 g, 0.02 mmol) and 5% Pd/C (0.6 g) in methanol (100 mL) was stirred under hydrogen (40 psi) at ambient temperature for two hours. The Pd catalyst was filtered off through a pad of Celite. After concentration of the filtrate, the resulting oily residue was triturated with MTBE (30 mL), which yielded a solid after standing at ambient temperature for one hour. The off-white solid was filtered, washed with MTBE (30 mL), and dried to furnish the title compound (5.4 g, 93% yield).

Provenance & Evidence