HuagongsheHuagongshe Chemistry Print Report · For research reference only
Reserpine → tert-butyl N-(4-bromo-3-methoxyphenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Reserpine | HCID 5770 | — |
| Reactant | 4-Bromo-3-methoxyaniline | HCID 7018254 | — |
| Reactant | Tert-butyl (5-bromo-2-methoxyphenyl)carbamate | HCID 17942658 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | tert-butyl N-(4-bromo-3-methoxyphenyl)carbamate | HCID 17942648 | — |
Reaction Steps
The compound was prepared from 4-bromo-3-methoxyaniline in the manner described for compound (2): 1H NMR (DMSO-d6, 400 MHz) δ 9.46 (s, 1H), 7.4 (d, 1H), 7.35 (s, 1H), 6.95 (d, 1H), 3.78 (s, 3H), 1.48 (s, 9H); TLC (heptane/ethyl acetate 8:2) Rf 0.37; RP-HPLC (Hypersil HyPurity Elite C18, 5 μm, 200 A, 250×4.6 mm; 25-100% acetonitrile-0.1 M ammonium acetate over 25 min, 1 ml/min) tr=18.60 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863444B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-41ed34840c26430db5ac6e128bf74d76 |
| Source note | uspto-grants-2011_01 |