1,4-Cyclohexadiene → HCID 10745775, compound

Participants

Reaction Steps

1.3 g of Trt-Gly-Gly-Phe-Gly-OBn (193) obtained in item (3) above was dissolved in 20 ml of DMF to obtain a solution. To the obtained solution were added 0.5 g of a 10% palladium-carbon catalyst and 0.4 g of 1,4-cyclohexadiene, followed by a reaction at room temperature for 30 minutes, to thereby obtain a reaction mixture. The obtained reaction mixture was subjected to filtration to remove the catalyst, thereby obtaining a solution. The solvents were distilled off from the obtained solution under reduced pressure. The resultant residue was purified by silica gel column chromatography (silica gel: Art No. 9365, Silica gel 60, 200-400 mesh, manufactured and sold by Merck KGaA, Germany; eluent: chloroform/methanol ratio=7/1), thereby obtaining 1.0 g of Trt-Gly-Gly-Phe-Gly (190).

Provenance & Evidence