Cyclohexanecarboxylic acid → HCID 19205727, compound

Under stirring, a solution of cyclohexanecarboxylic acid (10.0 g, 78 mmol) in MeOH (30 mL) was added dropwise over 30 min to 1 M lithium methoxide in MeOH (78 mL, 78 mmol) at 5-10° C. The cooling bath was removed and after 4 h at room temperature, heptane (75 mL) was added slowly. Most of the MeOH was removed at a rotary evaporator. Heptane (100 mL) was added to the thick white suspension which was stirred 2 h at 0° C. The suspension was filtered and the filter cake was washed with heptane and dried in vacuo (<1 mbar) to afford 10.5 g (100%) cyclohexanecarboxylic acid lithium salt. Anal. Calcd for C7H11LiO2 C, 62.70; H, 8.27. Found: C, 62.03; H, 8.11; H2O, 0.67.

1. customThe cooling bath was removed and after 4 h at room temperature
2. additionheptane (75 mL) was added slowly
3. customMost of the MeOH was removed at a rotary evaporator
4. additionHeptane (100 mL) was added to the thick white suspension which
5. stirringwas stirred 2 h at 0° C
6. filtrationThe suspension was filtered
7. washthe filter cake was washed with heptane
8. customdried in vacuo (<1 mbar)

ORD record

ord-f94055c7039542c09dac4dd54137f456

Source dataset

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07863474B2