反应详情

温度

85 °C

4-Dimethylaminobenzoyl chloride (1.00 g, 5 mmol) is added in one portion to a mixture of 4-hydroxymethyl-2,2-dimethyl-1,3-dioxolane (1.19 g, 10 mmol) and abs. pyridine (20 ml), and the mixture is stirred at room temperature for 10 min. The mixture is subsequently stirred at 80-90° C. for 2 h. Water (50 ml) is added, the reaction mixture is extracted with dichloromethane (3×25 ml), and the combined organic extracts are dried over magnesium sulfate. The solvent is removed in vacuo, and the residue is purified by column chromatography.

1. extractionthe reaction mixture is extracted with dichloromethane (3×25 ml)
2. dry with materialthe combined organic extracts are dried over magnesium sulfate
3. customThe solvent is removed in vacuo
4. customthe residue is purified by column chromatography