HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Afegostat | HCID 447607 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride | HCID 25105635 | — |
Reaction Steps
Isofagomine free base (30 mg) was dissolved in MeOH (5 mL) and 4 N HCl (0.5 mL) in isopropanol and acetone (4.0 mL). The sample was stored refrigerated overnight and filtered. Crystals were observed in the solution. However, when filtered, the product was a yellow substance having a glue-like consistency.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07863453B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-9da3c37ffb3d419a9cd6da97cf8321b3 |
| Source note | uspto-grants-2011_01 |