HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 251539Generated: October 29, 2026
2-(Methylamino)ethanol → 2-[(2-Fluoro-benzyl)-methyl-amino]-ethanol
https://huagongshe.com/reaction/251539
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | Benzenemethanol,2-fluoro-,1-methansulfonate | HCID 21964506 | — |
| Product | 2-[(2-Fluoro-benzyl)-methyl-amino]-ethanol | HCID 21964519 | — |
Reaction Steps
A mix of 2-Fluorobenzyl methanesulfonate (Step A, 5 g, 24.5 mmol) and 2-(Methylamino)-ethanol (18.4 g, 244.9 mmol) was heated under argon at 120° C. with stirring for 7 hours. The mixture was cooled to room temperature and concentrated. The crude residue was purified by flash chromatography on silica gel column (chloroform:methanol, 90:10 spiked with triethylamine) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07863475B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-37d7fbab3ab34519b38f8a3aad445a7b |
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| Source note | uspto-grants-2011_01 |
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