反应详情

A solution of (2S)-2-[(tert-butoxycarbonyl)amino]-8-oxodecanoic acid, EDC.HCl (1.3 eq.) and HOBt (1.3 eq.) in DMF was shaken for 5 min. To the mixture was added a solution of crude amine (L2) (1 eq.) and DIPEA (1 eq.) in DMF. The mixture was left to stir for 1 h. It was partitioned between DMF and 1 M NaOH. The DCM phase was washed sequentially with 1 M NaOH, 1 M HCl and brine, dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by chromatography on silica using 50% EtOAc/Petroleum ether as eluent to yield the product was obtained as a colourless oil. MS (ES) C27H36N2O5 requires: 468, found: 469 (M+H)+.

1. waitThe mixture was left
2. customIt was partitioned between DMF and 1 M NaOH
3. washThe DCM phase was washed sequentially with 1 M NaOH, 1 M HCl and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by chromatography on silica using 50% EtOAc/Petroleum ether as eluent
7. customto yield the product
8. customwas obtained as a colourless oil