Azide → HCID 90924656, compound

Participants

Reaction Steps

5-[1-azido-6-(2-ethyl-1,3-dioxolan-2-yl)hexyl]-2-phenyl-1,3-thiazole from alcohol (N2) was prepared according to the procedure used in Example 89 Step 2. 1H NMR (300 MHz, CDCl3) δ: 8.00-7.90 (2H, d, J=7.5 Hz), 7.57 (1H, s), 7.45-7.35 (3H, m), 5.10 (1H, t, J=7.3 Hz), 3.95 (4H, s), 1.89-1.78 (2H, m), 1.65-1.55 (4H, m), 1.45-1.25 (6H, m), 0.90-0.80 (3H, m). MS (ES) C20H26N4O2S requires: 386, found: 387 (M+H)+. The azide was then reduced according to the Example 89 Step 3 to afford the desired amine (N3). 1H NMR (300 MHz, CDCl3) δ: 7.95 (2H, d, J=7.5 Hz), 7.57 (1H, s), 7.45-7.35 (3H, m), 4.95 (1H, t, J=7.3 Hz), 3.95 (4H, s), 1.89-1.78 (2H, m), 1.65-1.55 (4H, m), 1.45-1.25 (6H, m), 0.90-0.80 (3H, m). MS (ES) C20H28N2O2S requires: 360, found: 361 (M+H)+.

Provenance & Evidence