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4-Bromophenacyl bromide → 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromophenacyl bromide | HCID 7454 | — |
| 反応物 | 2-Amino-5-methylpyridine | HCID 15348 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine | HCID 837893 | 81.3% |
反応手順
Dissolving 5 g (18 mmol) of 2,4′-dibromo acetophenone and 2.0 g (19 mmol) of 2-amino-5-picoline into 30 milliliter of ethanol, adding 2.9 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 6 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and ethanol, thereby obtaining 4.2 g of 2-(4-bromo-phenyl)-6-methyl-imidazo [1,2-a] pyridine (yield: 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07867629B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-31709fdeb18f48b3912546d8c56d8b63 |
| 出典メモ | uspto-grants-2011_01 |