反应详情

2.5 mg 10% Pd-C were added to the solution of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (50 mg, 0.2 mmol) in THF/MeOH 25 ml. The reaction mixture was stirred vigorously at room temperature for 4 h under hydrogen and the Pd—C was then removed. The filtrate was concentrated in vacuo to give the 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile as a yellow-white solid.

1. customthe Pd—C was then removed
2. concentrationThe filtrate was concentrated in vacuo