HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azane;hydrate → HCID 42623249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Reactant | HCID 57686802 | HCID 57686802 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 42623249 | HCID 42623249 | 70.2% |
Reaction Steps
3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)benzonitrile (6 mmol) in 40 ml MeOH and 30 ml THF was added Raney-Ni (0.6mmol) and 1 ml ammonia hydrate solution and stirred at room temperature for 4 h. Raney-Ni was removed and the filtrate was concentrated to yield (3-(imidazo[1,2-b]pyridazin-2-yl)-5-(2-methoxyethoxy)phenyl)methanamine (70.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868001B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-c1364b1b17ce4da9a88b41f196869608 |
| Source note | uspto-grants-2011_01 |