HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-3-chloropyridazine → 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Reactant | 3-(2-Bromoacetyl)benzonitrile | HCID 2735867 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | 52.8% |
Reaction Steps
A solution of 3-(2-bromoacetyl)benzonitrile and 6-chloropyridazin-3-amine (1 mmol) in EtOH was heated to reflux overnight. Then the mixture was cooled to r.t., and the precipitate was filtered to give 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile with a yield of 52.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868001B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-bb6d0969b60c4f5089b1237cf88c97de |
| Source note | uspto-grants-2011_01 |