HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| Product | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | 88.5% |
Reaction Steps
A mixture of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and Pd/C (20 mg) in DMF/THF (10 ml/10 ml) was stirred at r.t. for 6 h equipped with a H2 balloon. Then the solvent was removed under reduced pressure and 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile was obtained with a yield of 88.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868001B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-30420b1878484dd684c15607236eb653 |
| Source note | uspto-grants-2011_01 |