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Hydrochloric Acid → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 53439477 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid | HCID 57686812 | 60% |
反応手順
A solution of 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and 6M NaOH (2 ml) in EtOH was heated to reflux for 2 h. Then the mixture was diluted with water and acidified with HCl. The precipitate was filtered to give 3-(imidazo[1,2-b]pyridazin-2-yl)benzoic acid with a yield of 60%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07868001B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-2ba402ee2f5b4b6088104a6e4937924a |
| 出典メモ | uspto-grants-2011_01 |