HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → Tert-butyl 3-(imidazo[1,2-b]pyridazin-2-yl)phenylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 3-(Imidazo[1,2-b]pyridazin-2-yl)benzoic acid | HCID 57686812 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Tert-butyl 3-(imidazo[1,2-b]pyridazin-2-yl)phenylcarbamate | HCID 57686824 | 38.5% |
Reaction Steps
A solution of 3-(imidazo[1,2-b]pyridazin-2-yl)benzoic acid (1 mmol), DPPA (3 mmol) and Et3N (3 mmol) in toluene was heated to reflux for 4 h. Then t-BuOH (1 ml) was added and reflux was continued overnight. Water was added, and the mixture was extracted with EtOAc. The organic layer was washed with diluted HCl, brine and NaHCO3 (aq), and was concentrated to give a solid. After purification by chromatography, tert-butyl 3-(imidazo[1,2-b]pyridazin-2-yl)phenylcarbamate was obtained with a yield of 38.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868001B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-f6d90c18b4634b25988bd7cb889cefb5 |
| Source note | uspto-grants-2011_01 |