HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-(Imidazo[1,2-b]pyridazin-2-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Tert-butyl 3-(imidazo[1,2-b]pyridazin-2-yl)phenylcarbamate | HCID 57686824 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(Imidazo[1,2-b]pyridazin-2-yl)aniline | HCID 57686808 | 75% |
Reaction Steps
A solution of tert-butyl 3-(imidazo[1,2-b]pyridazin-2-yl)phenylcarbamate (1 mmol) and TFA (4 mmol) in CH2Cl2 (10 ml) was stirred at 35° C. overnight. Then 1 M NaOH (4 ml) was added, and the mixture was extracted with EtOAc. The organic layer was concentrated to give 3-(imidazo[1,2-b]pyridazin-2-yl)aniline with a yield of 75%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868001B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-f5f1de3f0c1449049edd3620f70e0fb9 |
| Source note | uspto-grants-2011_01 |