1-(Morpholinocarbonylmethyl)piperazine → HCID 59028011, compound

HRID 251848Notes

Reaction equation

HRID 251848 reaction equation
[N:1]1([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[C:18](F)=[C:19]([F:35])[CH:20]=[C:21]2[C:26]=1[N:25]([C@H:27]1[CH2:29][C@H:28]1[F:30])[CH:24]=[C:23]([C:31]([OH:33])=[O:32])[C:22]2=[O:34]>>[Cl:16][C:17]1[C:18]([N:4]2[CH2:3][CH2:2][N:1]([CH2:7][C:8]([N:10]3[CH2:11][CH2:12][O:13][CH2:14][CH2:15]3)=[O:9])[CH2:6][CH2:5]2)=[C:19]([F:35])[CH:20]=[C:21]2[C:26]=1[N:25]([C@H:27]1[CH2:29][C@H:28]1[F:30])[CH:24]=[C:23]([C:31]([OH:33])=[O:32])[C:22]2=[O:34]

Participants

3

Reactant 2

HCID 1006221-(Morpholinocarbonylmethyl)piperazineHCID 9995973HCID 9995973, compound

Product 1

HCID 59028011HCID 59028011, compound

Procedure

The preparation takes place in analogy to Example 1A from 4-[2-(piperazin-1-yl)acetyl]morpholine and 8-chloro-6,7-difluoro-1-[(1S,2R)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (for preparation see Journal of Medicinal Chemistry (1994) 37:3344-3352). The compound is used as a crude product in the subsequent reaction stages.

Sources & evidence

ORD record
ord-f45fc3178af94c2e9a68058ec20aa9c9
Source dataset
uspto-grants-2011_01
Patent number
US07867992B2

Reaction notes

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