反应详情

588 mg of 2-bromo-4-chlorobenzoic acid and 300 mg of urea are dissolved in dichloromethane/methanole and deposited onto 364 mg of aluminum oxide on a rotary evaporator. The residue is irradiated for 60 min in a microwave at 150° C. After cooling the residue is stirred with ethyl acetate and water, the mixture is filtered and the aqueous phase is removed. The organic phase is washed with a sodium hydrogencarbonate solution dried over sodium sulfate, concentrated on a rotary evaporator and then dried under high vacuum. The product is reacted further without additional purification.

1. customdeposited onto 364 mg of aluminum oxide on a rotary evaporator
2. customThe residue is irradiated for 60 min in a microwave at 150° C
3. temperatureAfter cooling the residue
4. filtrationthe mixture is filtered
5. customthe aqueous phase is removed
6. washThe organic phase is washed with a sodium hydrogencarbonate solution
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated on a rotary evaporator
9. customdried under high vacuum
10. customThe product is reacted further without additional purification