HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 251864Generated: October 30, 2026
Acrylamide → 7-[(3RS,5SR)-4-(3-Amino-3-oxopropyl)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-N-[2-methyl-4-(trifluoromethoxy)benzyl]-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide
https://huagongshe.com/reaction/251864
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylamide | HCID 6579 | — |
| Reactant | Lithium perchlorate | HCID 23665649 | — |
| Reactant | 7-[(3RS,5SR)-3,5-Dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-N-[2-methyl-4-(trifluoromethoxy)benzyl]-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide | HCID 72493844 | — |
| Catalyst | Acetonitrile | HCID 6342 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 7-[(3RS,5SR)-4-(3-Amino-3-oxopropyl)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-N-[2-methyl-4-(trifluoromethoxy)benzyl]-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide | HCID 72493816 | — |
Reaction Steps
A few drops of acetonitrile are added at room temperature to 55 mg of the compound of Example 52, 18 mg of acrylamide and 35 mg of lithium perchlorate, so that a stirrable suspension results. The mixture is heated to 70° C. over night and left to cool. After the addition of DMSO the whole mixture is separated by preparative HPLC (Method 5). After concentrating the suitable fractions and drying under high vacuum 30 mg (40% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07867992B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-0b93aa94662c4e62b1e0a9feeacf9e77 |
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| Source note | uspto-grants-2011_01 |
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