Sulfuric Acid → HCID 66864492, compound

HRID 251870Notes

Reaction equation

HRID 251870 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8](O)[CH2:9][N:10]([CH:20]1[CH2:22][CH2:21]1)[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[Cl:19].S(=O)(=O)(O)O>>[Cl:18][C:15]1[CH:16]=[C:17]2[C:12](=[C:13]([Cl:19])[CH:14]=1)[CH2:11][N:10]([CH:20]1[CH2:22][CH2:21]1)[CH2:9][CH:8]2[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH2:1]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 59682870HCID 59682870, compound

Product 1

HCID 66864492HCID 66864492, compound

Procedure

The three fractions can all, as described below for 1-(2-aminophenyl)-2-[cyclopropyl-(2,4-dichlorobenzyl)amino]ethanol under b), be cyclized with sulfuric acid to give 2-(6,8-dichloro-2-cyclopropyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine.

Sources & evidence

ORD record
ord-64fbd08436c94b2398b9b01e5363d450
Source dataset
uspto-grants-2011_01
Patent number
US07868003B2

Reaction notes

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