HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 11626155, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 66865035 | HCID 66865035 | — |
| Reactant | HCID 66865129 | HCID 66865129 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 11626155 | HCID 11626155 | 20.1% |
Reaction Steps
Analogously to example 49, ((R)-5-oxo-2-trichloromethyl[1,3]dioxolan-4-yl)acetic acid (94 mg, see Synthesis 2002, 2165), thionyl chloride (2 ml) and 2-((R)-6,8-dichloro-2-cyclopropyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine trifluoroacetic acid salt (200 mg) were reacted. The freeze-drying from water/acetonitrile afforded 31 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868003B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-f413bedbe0a9425497babea6d2b0b802 |
| Source note | uspto-grants-2011_01 |