反应详情

In a hydrogenation apparatus, a spatula-tip of palladium on activated carbon (5%) was added to a solution of 1-[2-((R)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]pyrrolidine-2,5-dione (68 mg, example 7) in methanol (15 ml), and, after application of a hydrogen atmosphere, agitated for 2 h. After the hydrogen had been removed, the apparatus was left to stand under argon overnight, and then the catalyst was filtered off and washed with methanol. The filtrate was concentrated to dryness. 10 mg of the crude product were taken up with water and 10% hydrochloric acid and freeze-dried. 10 mg of the title compound were obtained.

1. customAfter the hydrogen had been removed
2. waitthe apparatus was left
3. filtrationthe catalyst was filtered off
4. washwashed with methanol
5. concentrationThe filtrate was concentrated to dryness
6. customfreeze-dried