反应详情

A mixture of 1.05 g of 6-chloro-8-methyl-1H-benzo[d]-1,3-oxazine-2,4-dione, 0.46 g of methyl carbazate and 20 ml of methanol was heated to reflux for 3 hours. After the reaction mixture was allowed to cool to around room temperature, water was poured thereto and the mixture was extracted with ethyl acetate three times. The resulting organic layer was concentrated under reduced pressure, and the residue was washed with toluene to obtain 0.77 g of N-(2-amino-5-chloro-3-methylbenzoyl)-N′-methoxycarbonylhydrazine of the formula:

1. temperaturewas heated
2. temperatureto reflux for 3 hours
3. temperatureto cool to around room temperature
4. extractionthe mixture was extracted with ethyl acetate three times
5. concentrationThe resulting organic layer was concentrated under reduced pressure
6. washthe residue was washed with toluene