Formic Acid → HCID 86087806, compound

HRID 251955Notes

Reaction equation

HRID 251955 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[CH:11][C:10]([CH:13](OC)[O:14]C)=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C(O)=O>O>[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[CH:11][C:10]([CH:13]=[O:14])=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 66853879HCID 66853879, compound

Product 1

HCID 86087806HCID 86087806, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 3.35 g of 3-chloro-2-[3-(dimethoxymethyl)-1H-pyrazol-1-yl]pyridine, 24 ml of formic acid and 6 ml of water was stirred at 60° C. for 1 hour. The reaction mixture was concentrated under reduced pressure. Ice water was poured into the residue, and a precipitated solid was collected by filtration to obtain 2.38 g of 1-(3-chloro-2-pyridinyl)-1H-pyrazole-3-carbaldehyde of the formula:

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionIce water was poured into the residue
  3. filtrationa precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-7f6c1a2e9b7c471a8ae5dd5d59692662
Source dataset
uspto-grants-2011_01
Patent number
US07867949B2

Reaction notes

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