HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-bromo-1-(3-chloro-4-pyridinyl)-1H-pyrrole-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-(3-chloro-4-pyridinyl)-1H-pyrrole-2-carbaldehyde | HCID 86632559 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-bromo-1-(3-chloro-4-pyridinyl)-1H-pyrrole-2-carbaldehyde | HCID 86632560 | 29.4% |
Reaction Steps
To a solution of 2.95 g of 1-(3-chloro-4-pyridinyl)-1H-pyrrole-2-carbaldehyde in 20 ml of N,N-dimethylformamide was added 2.66 g of N-bromosuccinimide. The resulting mixture was stirred at room temperature for 10 hours. Water was poured into the reaction mixture, and a deposited precipitate was collected by filtration to obtain 1.2 g of 4-bromo-1-(3-chloro-4-pyridinyl)-1H-pyrrole-2-carbaldehyde of the formula:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07867949B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-5dff8bfbe2ff4ffe9faeae71b432ca78 |
| Source note | uspto-grants-2011_01 |