HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 252008Generated: October 29, 2026
Dimethylformamide → 2-(4-bromo-1H-imidazol-1-yl)-3-chloropyridine
https://huagongshe.com/reaction/252008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Chloro-2-methanesulfonylpyridine | HCID 13433425 | — |
| Reactant | HCID 178418934 | HCID 178418934 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-bromo-1H-imidazol-1-yl)-3-chloropyridine | HCID 66853887 | 96.9% |
Reaction Steps
A mixture of 1.0 g of 4-bromoimidazole, 1.3 g of 3-chloro-2-(methanesulfonyl)pyridine, 2.7 g of cesium carbonate and 10 ml of N,N-dimethylformamide was stirred at 100° C. for 6 hours. The reaction mixture was allowed to cool to room temperature, and water was poured into the mixture. A deposited precipitate was collected by filtration to obtain 1.7 g of 2-(4-bromo-1H-imidazol-1-yl)-3-chloropyridine of the formula:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07867949B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-e1ef04f8f5c64eab93bd4516a8c39560 |
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| Source note | uspto-grants-2011_01 |
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