HuagongsheHuagongshe Chemistry Print Report · For research reference only
TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE → tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE | HCID 11680504 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate | HCID 22240520 | 98.5% |
Reaction Steps
A solution of 5-nitro-indole-1-carboxylic acid tert-butyl ester (0.50 g) and catalytic amount of Pd(OH)2 in a mixture of MeOH-EtOAc was stirred at room temperature under hydrogen for 1 h. The reaction mixture was filtered through celite and the filtrate was concentrated to provide 5-amino-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (0.44 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868002B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-613fa916f9dd4d5f97dde07a190c8e64 |
| Source note | uspto-grants-2011_01 |