1-Methylpiperazine → HCID 16039641, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonic acid 5-[7-methyl-1-oxo-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-1H-isoindol-5-yl]-pyridin-3-ylmethyl ester (36 mg, 0.071 mmol) was dissolved in THF (5 mL). N-Methyl piperazine (24 uL, 0.213 mmol) was added and the mixture stirred at 50° C. for 18 hrs. The mixture was cooled, diluted with water, and extracted with ethyl acetate. The organics were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Column chromatography (5% 2M NH3 in MeOH/CH2Cl2) provided the title compound (24 mg, 67%) as a yellow oil. 1H NMR (300 MHz, CDCl3): δ 8.73 (s, 1H), 8.56 (s, 1H), 7.86 (s, 1H), 7.42 (d, 2H), 7.37 (d, 2H), 7.19 (d, 2H), 4.82 (s, 2H), 4.32 (s, 2H), 3.60 (s, 2H), 2.85 (s, 3H), 2.52-2.42 (br s, 8H), 2.30 (s, 3H).

Provenance & Evidence