(E)-7((5-Methyl-1H-imidazol-4-yl)methylene)-6,7-dihydroquinolin-8(5H)-one → 7-((5-Methyl-1H-imidazol-4-yl)methyl)-6,7-dihydroquinolin-8(5H)-one

関与物質

反応手順

A mixture of (4) (1.39 g, 5.81 mmol) and Pd/BaSO4 (5 wt %, 0.47 g) in methanol and chloroform was hydrogenated at 50 psi for one hour. The reaction mixture was filtered through a bed of Celite, and washed with methanol. The solvents were removed under vacuum. The crude product was purified by chromatography on silica gel with 2 to 3% ammonia saturated methanol in dichloromethane to give 7-((5-Methyl-1H-imidazol-4-yl)methyl)-6,7-dihydroquinolin-8(5H)-one (5) as a yellow oil (0.830 g, 344 mmol, 59% yield).

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