Dichloromethane → HCID 66856299, compound

Participants

Reaction Steps

Add trifluoroacetic acid (20 mL) to a solution of (S)-[1-(5-bromopyrimidin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (3.66 g, 10.7 mmol) in dichloromethane (20 mL). Stir 2 h and concentrate. Dissolve the residue in methanol and pass through a column of Amberjet® 4400 resin (OH-form). Wash the column with methanol and concentrate the eluant. Dissolve the residue in methanol/acetonitrile and add 1 N HCl (25 mL) in methanol. Collect the resulting solid by filtration, wash with acetonitrile and dry the solid to give (S)-1-(5-bromopyrimidin-2-yl)-pyrrolidin-3-ylamine hydrochloride as a tan solid (2.55 g, 85%).

Provenance & Evidence