HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 252135Generated: October 25, 2026
Formic Acid → 4-Chloro-2-(trifluoromethyl)benzaldehyde
https://huagongshe.com/reaction/252135
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Chloro-2-(trifluoromethyl)benzonitrile | HCID 2773495 | — |
| Catalyst | Nickel aluminide | HCID 6336846 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Chloro-2-(trifluoromethyl)benzaldehyde | HCID 2779017 | 87% |
Reaction Steps
Add 4-chloro-2-trifluoromethyl-benzonitrile to formic acid (96%) (15 mL) and water (3 mL). Add nickel-aluminum alloy (1260 mg). Heat at 100° C. overnight. Dilute with ethyl acetate and filter through Celite®. Extract the filtrate with 1 N sodium hydroxide and saturated aqueous sodium chloride, dry (sodium sulfate), filter, and concentrate to give 4-chloro-2-trifluoromethylbenzaldehyde (555 mg, 87%): 1H NMR (400 MHz, MeOH-d4) δ 10.29 (m, 1H), 8.10 (d, 1H, J=8.4 Hz), 7.91 (d, 1H, J=1.6 Hz), 7.85 (dd, 1H, J=8.4, 1.6 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07868014B2 |
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| Source dataset | uspto-grants-2011_01 |
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| ORD ID | ord-d0908532718b44929471bf42459ef1dd |
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| Source note | uspto-grants-2011_01 |
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