HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminomethyl-1-ethylpyrrolidine → 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}methanesulfonylmethyl)-N-(1-ethylpyrrolidin-2-ylmethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | 3-({1-[Bis(4-chlorophenyl)methyl]azetidin-3-ylidene}methanesulfonylmethyl)benzoic acid | HCID 69635678 | — |
| Product | 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}methanesulfonylmethyl)-N-(1-ethylpyrrolidin-2-ylmethyl)benzamide | HCID 69635683 | — |
Reaction Steps
The operation is carried out under the conditions described in Example 124 starting with 150 mg of activated 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}methanesulfonylmethyl)benzoic acid on TFP resin (165 μM) and 0.0396 cm3 of 2-(aminomethyl)-N-ethylpyrrolidine. 58 mg of 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}methanesulfonylmethyl)-N-(1-ethylpyrrolidin-2-ylmethyl)benzamide are thus obtained in the form of an ochre-colored foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858603B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-39a5f7da03d24d749f2c4900d49b0e3b |
| Source note | uspto-grants-2005_02 |