2-Benzylsulphanyl-4-chlorobenzamide → Ticlatone

HRID 252155Notes

Reaction equation

HRID 252155 reaction equation
ClC1C=CC2SN=C(O)C=2C=1.C([S:19][C:20]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:21]=1[C:22]([NH2:24])=[O:23])C1C=CC=CC=1>>[Cl:29][C:27]1[CH:26]=[CH:25][C:21]2[C:22]([OH:23])=[N:24][S:19][C:20]=2[CH:28]=1

Participants

3

Reactant 2

HCID 574851312-Benzylsulphanyl-4-chlorobenzamideHCID 178519009HCID 178519009, compound

Product 1

HCID 6258Ticlatone

Procedure

A method similar to the preparation of 5-chlorobenzo[d]isothiazol-3-ol (see pages 17 and 18 above) was followed using 2-benzylsulphanyl-4-chlorobenzamide (350 mg, 1.26 mmol). The title compound was isolated as a white solid (150 mg, 64%).

Sources & evidence

ORD record
ord-241e31ca728a47c1977b7c2d8249b977
Source dataset
uspto-grants-2011_01
Patent number
US07868017B2

Reaction notes

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