Dimethyl Sulfoxide → HCID 24752503, compound

Participants

Reaction Steps

Sodium methane thiolate (0.42 g, 6.0 mmol) was added to a suspension of N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-chlorobenzenesulfonamide (0.60 g, 1.5 mmol) in methanol (30 ml). The mixture was heated under refluxed for 60 hours and concentrated under reduced pressure. A part of the crude (80 mg) was dissolved in acetonitrile-water and acidified using acetic acid. The precipitate formed was redissolved in DMSO and purified by preparative RP-HPLC: 14 mg lyophilisate, MS: m/e 362.1 (MH−).

Provenance & Evidence