HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3-methylthiophene → 2-fluoro-5-(3-methylthiophen-2-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3-methylthiophene | HCID 84314 | — |
| Reactant | (6-Fluoropyridin-3-yl)boronic acid | HCID 2783397 | — |
| Product | 2-fluoro-5-(3-methylthiophen-2-yl)pyridine | HCID 11148236 | 75.9% |
Reaction Steps
This compound was prepared in analogy to Example 52, starting from 2-bromo-3-methylthiophene (2.6 g, 15 mmol) and 2-fluoro-5-pyridine-boronic acid (2.3 g, 16.5 mmol, 1.1 equiv.) to obtain 2.2 g of the desired compound as a light yellow oil. MS (ES): m/e 194.2 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07868030B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-208d82ef32d04263a4465caff55dc60f |
| Source note | uspto-grants-2011_01 |