反应详情

4-Methoxymethyl-thiazol-2-ylamine (170 mg, 1.1 mmol) is dissolved in acetonitrile and N-bromosuccinimide. (231 mg, 1.3 mmol, 1.1 equiv.) was added in one portion. The mixture was stirred at room temp. for 2 hours, then filtered and the filtrate was evaporated. After purification on silica-gel with ethyl acetate/n-heptane as eluent, 260 mg of a light red solid were obtained: MS: m/e 222.8 (M+H).

1. addition(231 mg, 1.3 mmol, 1.1 equiv.) was added in one portion
2. filtrationfiltered
3. customthe filtrate was evaporated
4. customAfter purification on silica-gel with ethyl acetate/n-heptane as eluent